I present the motivation for experiments which attempt to generate, and verify the existence of, quantum superpositions of two or more states which are by some reasonable criterion "macroscopically" distinct, and show that various a priori objections to this program made in the literature are flawed. I review the extent to which such experiments currently exist in the areas of free-space molecular diffraction, magnetic biomolecules, quantum optics and Josephson devices, and sketch possible future lines of development of the program.